THROMBOTIC AND BLEEDING RISK FACTORS IN ESSENTIAL THROMBOCYTHEMIA
نویسندگان
چکیده
منابع مشابه
The expression pattern of c-mpl in megakaryocytes correlates with thrombotic risk in essential thrombocythemia.
Using immunohistochemistry, we investigated the expression of c-mpl in bone marrow megakaryocytes of 88 patients with essential thrombocythemia (ET), 6 patients with secondary thrombocytosis (ST), and 20 patients with lymphoma (controls). Considering both the pattern of expression and the staining intensity, we identified a uniform and a heterogeneous pattern of c-mpl expression. The uniform pa...
متن کاملThrombotic risk assessment in 185 WHO-defined essential thrombocythemia patients: single center experience
Thrombosis risk in essential thrombocythemia (ET) patients can be assessed using different prognostic systems. Conventional risk factors include age more than 60 years and history of previous thrombosis. In addition, other factors such as JAK2 V617F mutations, cardiovascular risk factors, leukocytosis more than 11 × 10(9)/l, thrombophilic factors and platelet count more than 1500 × 10(9)/l are ...
متن کاملJAK2 mutation status, hemostatic risk factors and thrombophilic factors in essential thrombocythemia (ET) patients.
The recently discovered JAK2 V617F point mutation, found in 50-60% of ET patients, has been reported to be associated with a higher risk of thrombotic events. In this study, we explored if JAK2 V617F mutation, or coexisting thrombophilic and hemostatic risk factors, contributed to these complications. We examined 32 patients with ET, and looked for pathogenetic JAK2 V617F mutation and prothromb...
متن کاملEssential thrombocythemia
Essential thrombocythemia (ET) is an acquired myeloproliferative disorder (MPD) characterized by a sustained elevation of platelet number with a tendency for thrombosis and hemorrhage. The prevalence in the general population is approximately 30/100,000. The median age at diagnosis is 65 to 70 years, but the disease may occur at any age. The female to male ratio is about 2:1. The clinical pictu...
متن کاملMPL mutations and palpable splenomegaly are independent risk factors for fibrotic progression in essential thrombocythemia
Essential thrombocythemia (ET) belongs to the World Health Organization (WHO) tumor category of myeloproliferative neoplasms (MPN). ET is characterized by clonal thrombocytosis and its diagnosis requires absence of molecular or morphologic evidence of other myeloid malignancies including chronic myeloid leukemia, polycythemia vera, primary myelofibrosis (PMF), myelodysplastic syndromes or myelo...
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ژورنال
عنوان ژورنال: Oncohematology
سال: 2017
ISSN: 2413-4023,1818-8346
DOI: 10.17650/1818-8346-2017-12-2-30-38